Ca2+current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells
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چکیده
منابع مشابه
beta-adrenergic receptor-mediated presynaptic facilitation of inhibitory GABAergic transmission at cerebellar interneuron-Purkinje cell synapses.
Norepinephrine (NE) has been shown to elicit long-term facilitation of GABAergic transmission to rat cerebellar Purkinje cells (PCs) through beta-adrenergic receptor activation. To further examine the locus and adrenoceptor subtypes involved in the NE-induced facilitation of GABAergic transmission, we recorded inhibitory postsynaptic currents (IPSCs) evoked by focal stimulation with paired-puls...
متن کاملb-Adrenergic Receptor-Mediated Presynaptic Facilitation of Inhibitory GABAergic Transmission at Cerebellar Interneuron- Purkinje Cell Synapses
Saitow, Fumihito, Shin’Ichiro Satake, Junko Yamada, and Shiro Konishi. b-Adrenergic receptor-mediated presynaptic facilitation of inhibitory GABAergic transmission at cerebellar interneuron-Purkinje cell synapses. J Neurophysiol 84: 2016–2025, 2000. Norepinephrine (NE) has been shown to elicit long-term facilitation of GABAergic transmission to rat cerebellar Purkinje cells (PCs) through b-adre...
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19 Aplysia sensorimotor synapses provide a useful model system for analyzing molecular 20 processes that contribute to heterosynaptic plasticity. For example, previous studies 21 demonstrated that multiple kinase cascades contribute to serotonin (5-HT)-induced 22 short-term synaptic facilitation (STF), including protein kinase A (PKA) and protein 23 kinase C (PKC). Moreover, the contribution of...
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The teleost Mauthner (M)-cell is subjected to a powerful glycinergic inhibition that regulates its threshold for initiation of a vital escape reflex. The effects of 5-HT on this inhibition were studied in current- and voltage-clamp experiments because the M-cell and its afferents have a profuse serotonergic innervation, including axoaxonal contacts with terminals of the inhibitory interneurons....
متن کاملEfficacy and short-term plasticity at GABAergic synapses between Purkinje and cerebellar nuclei neurons.
Although the entire output of the cerebellar cortex is conveyed to the deep cerebellar nuclei neurons (DCNs) via the GABAergic synapses established by Purkinje cells (PCs), very little is known about the strength and dynamic properties of PC-DCN connections. Here we show that activation of PC-DCN unitary connections induced large conductance changes (11.7 nS) in DCNs recorded in whole cell patc...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2015
ISSN: 0022-3751
DOI: 10.1113/jp270704